Norway detects "probable" case of mad cow disease
Norway said Wednesday it had detected a "probable" case of mad cow disease
but urged consumers not to panic as it may not be the same variant as the
British 1990s epidemic.
A second positive test for bovine spongiform encephalopathy (BSE) on a
15-year-old cow reinforced suspicions that it had mad cow disease, the Norwegian
Veterinary Institute said.
"We have a likely and strong suspicion of a possible variant of BSE,"
Bjoern Roethe Knudtsen of the Food and Safety Authority told public broadcaster
NRK.
The authorities however said there was a distinction between the type of
BSE caused by cows eating meat-based feed—banned in Europe since 2001 after the
British epidemic—and an atypical version which has sporadically appeared in
older cows in several European countries in recent years.
A definitive diagnosis can only be made by a European reference laboratory
in Britain.
"We take this seriously and we are handling it as if our suspicion were
confirmed," Food and Safety Authority official Solfrid Aamdal said in a
statement.
The authority stressed that "more and more" BSE cases in Europe are of the
atypical kind and that beef and milk consumption remains safe.
The cow's carcass, from a farm in west-central Norway, was destroyed and
safety measures put in place for the rest of the herd.
sporadic or spontaneous excuse for the atypical BSE cases have never been
proven. it’s a myth. ...
atypical BSE a spontaneous event ???
if that's the case, then France is having one hell of an epidemic of
atypical BSE, probably why they stopped testing for BSE $$$
Sunday, October 5, 2014
France stops BSE testing for Mad Cow Disease
Thursday, July 24, 2014
*** Protocol for further laboratory investigations into the distribution of
infectivity of Atypical BSE SCIENTIFIC REPORT OF EFSA New protocol for Atypical
BSE investigations
>>> The generally older age of the identified H-BSE and L-BSE
cases, and their apparently low prevalence in the population, suggest that these
Atypical BSE forms could be arising spontaneously.
if that is the case, then FRANCE has an exceedingly high rate of
spontaneous atypical BSE cases.
*** Singeltary reply ; Molecular, Biochemical and Genetic Characteristics
of BSE in Canada Singeltary reply ;
SUMMARY REPORT CALIFORNIA ATYPICAL L-TYPE BOVINE SPONGIFORM ENCEPHALOPATHY
CASE INVESTIGATION JULY 2012 CALIFORNIA
Summary Report BSE 2012
Executive Summary
Saturday, August 4, 2012
Final Feed Investigation Summary - California atypical L-type BSE Case -
July 2012
Saturday, August 4, 2012
Update from APHIS Regarding Release of the Final Report on the BSE
Epidemiological Investigation
Tuesday, December 23, 2014
FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2014 BSE TSE PRION
Friday, December 5, 2014
***SPECIAL ALERT The OIE recommends strengthening animal disease
surveillance worldwide
Sunday, December 28, 2014
*** Reverse Freedom of Information Act request rFOIA FSIS USDA APHIS TSE
PRION aka BSE MAD COW TYPE DISEASE December 2014
IN A NUT SHELL ;
(Adopted by the International Committee of the OIE on 23 May 2006)
11. Information published by the OIE is derived from appropriate
declarations made by the official Veterinary Services of Member Countries. The
OIE is not responsible for inaccurate publication of country disease status
based on inaccurate information or changes in epidemiological status or other
significant events that were not promptly reported to the Central Bureau,
Transmissible Spongiform Encephalopathy TSE Prion Disease North America
2014
Transmissible Spongiform Encephalopathy TSE Prion Disease have now been
discovered in a wide verity of species across North America. typical C-BSE,
atypical L-type BASE BSE, atypical H-type BSE, atypical H-G BSE, of the bovine,
typical and atypical Scrapie strains, in sheep and goats, with atypical Nor-98
Scrapie spreading coast to coast in about 5 years. Chronic Wasting Disease CWD
in cervid is slowly spreading without any stopping it in Canada and the USA and
now has mutated into many different strains. Transmissible Mink Encephalopathy
TME outbreaks. These Transmissible Spongiform Encephalopathy TSE Prion Disease
have been silently mutating and spreading in different species in North America
for decades. The USDA, FDA, et al have assured us of a robust Triple BSE TSE
prion Firewall, of which we now know without a doubt, that it was nothing but
ink on paper. Since the 1997 mad cow feed ban in the USA, literally tons and
tons of banned mad cow feed has been put out into commerce, never to return, as
late as December of 2013, serious, serious breaches in the FDA mad cow feed ban
have been documented. The 2004 enhanced BSE surveillance program was so flawed,
that one of the top TSE prion Scientist for the CDC, Dr. Paul Brown stated ;
Brown, who is preparing a scientific paper based on the latest two mad cow cases
to estimate the maximum number of infected cows that occurred in the United
States, said he has "absolutely no confidence in USDA tests before one year ago"
because of the agency's reluctance to retest the Texas cow that initially tested
positive.
see ; http://www.upi.com/Health_News/2006/03/15/Analysis-What-that-mad-cow-means/UPI-12841142465253/
The BSE surveillance and testing have also been proven to be flawed, and
the GAO and OIG have both raised serious question as to just how flawed it has
been (see GAO and OIG reports). North America has more documented TSE prion
disease, in different documented species (excluding the Zoo BSE animals in the
EU), then any other place on the Globe. This does not include the very
likelihood that TSE prion disease in the domestic feline and canine have been
exposed to high doses of the TSE prion disease vid pet food. To date, it’s still
legal to include deer from cwd zone into pet food or deer food. Specified Risk
Material i.e. SRM bans still being breach, as recently as just last month. nvCJD
or what they now call vCJD, another case documented in Texas last month, with
very little information being released to the public on about this case? with
still the same line of thought from federal officials, ‘it can’t happen here’,
so another vCJD blamed on travel of a foreign animal disease from another
country, while ignoring all the BSE TSE Prion risk factors we have here in the
USA and Canada, and the time that this victim and others, do spend in the USA,
and exposed to these risk factors, apparently do not count in any way with
regard to risk factor. a flawed process of risk assessment. sporadic CJD, along
with new TSE prion disease in humans, of which the young are dying, of which
long duration of illness from onset of symptoms to death have been documented,
only to have a new name added to the pot of prion disease i.e. sporadic GSS,
sporadic FFI, and or VPSPR. I only ponder how a familial type disease could be
sporadic with no genetic link to any family member? when the USA is the only
documented Country in the world to have documented two different cases of
atypical H-type BSE, with one case being called atypical H-G BSE with the G
meaning Genetic, with new science now showing that indeed atypical H-type BSE is
very possible transmitted to cattle via oral transmission (Prion2014). sporadic
CJD and VPSPR have been rising in Canada, USA, and the UK, with the same old
excuse, better surveillance. You can only use that excuse for so many years, for
so many decades, until one must conclude that CJD TSE prion cases are rising. a
48% incease in CJD in Canada is not just a blip or a reason of better
surveillance, it is a mathematical rise in numbers. More and more we are seeing
more humans exposed in various circumstance in the Hospital, Medical, Surgical
arenas to the TSE Prion disease, and at the same time in North America, more and
more humans are becoming exposed to the TSE prion disease via consumption of the
TSE prion via deer and elk, cattle, sheep and goats, and for those that are
exposed via or consumption, go on to further expose many others via the
iatrogenic modes of transmission of the TSE prion disease i.e. friendly fire. I
pondered this mode of transmission via the victims of sporadic FFI, sporadic
GSS, could this be a iatrogenic event from someone sub-clinical with sFFI or
sGSS ? what if?
Two decades have passed since Dr. Ironside first confirmed his first ten
nvCJD victims in 1995. Ten years later, 2005, we had Dr. Gambetti and his first
ten i.e. VPSPR in younger victims. now we know that indeed VPSPR is
transmissible. yet all these TSE prion disease and victims in the USA and Canada
are being pawned off as a spontaneous event, yet science has shown, the
spontaneous theory has never been proven in any natural case of TSE prion
disease, and scientist have warned, that they have now linked some sporadic CJD
cases to atypical BSE, to atypical Scrapie, and to CWD, yet we don’t here about
this in the public domain. We must make all human and animal TSE prion disease
reportable in every age group, in ever state and internationally, we must have a
serious re-evaluation and testing of the USA cattle herds, and we must ban
interstate movement of all cervids. Any voluntary effort to do any of this will
fail. Folks, we have let the industry run science far too long with regards to
the TSE prion disease. While the industry and their lobbyist continues to funnel
junk science to our decision policy makers, Rome burns. ...end
REFERENCES
Sunday, June 29, 2014
Transmissible Spongiform Encephalopathy TSE Prion Disease North America
2014
Saturday, January 17, 2015
*** Becky Lockhart 46, Utah’s first female House speaker, dies diagnosed
with the extremely rare Creutzfeldt-Jakob disease
who’s kidding whom $$$ i.e. USDA INC AND THE OIE
2014
***Moreover, L-BSE has been transmitted more easily to transgenic mice
overexpressing a human PrP [13,14] or to primates [15,16] than C-BSE.
***It has been suggested that some sporadic CJD subtypes in humans may
result from an exposure to the L-BSE agent. Lending support to this hypothesis,
pathological and biochemical similarities have been observed between L-BSE and
an sCJD subtype (MV genotype at codon 129 of PRNP) [17], and between L-BSE
infected non-human primate and another sCJD subtype (MM genotype) [15].
snip...
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion
strains in transgenic mice expressing human prion protein
*** Surprisingly, however, BSE transmission to these transgenic mice, in
addition to producing a vCJD-like phenotype, can also result in a distinct
molecular phenotype that is indistinguishable from that of sporadic CJD with
PrPSc type 2.
These data suggest that more than one BSEderived prion strain might infect
humans;
***it is therefore possible that some patients with a phenotype consistent
with sporadic CJD may have a disease arising from BSE exposure.
snip...
These studies further strengthen the evidence that vCJD is caused by a
BSE-like prion strain.
Also, remarkably, the key neuropathological hallmark of vCJD, the presence
of abundant florid PrP plaques, can be recapitulated on BSE or vCJD transmission
to these mice.
***However, the most surprising aspect of the studies was the finding that
an alternate pattern of disease can be induced in 129MM Tg35 mice from primary
transmission of BSE, with a molecular phenotype indistinguishable from that of a
subtype of sporadic CJD. This finding has important potential implications as it
raises the possibility that some humans infected with BSE prions may develop a
clinical disease indistinguishable from classical CJD associated with type 2
PrPSc. This is, in our experience, the commonest molecular sub-type of sporadic
CJD. In this regard, it is of interest that the reported incidence of sporadic
CJD has risen in the UK since the 1970s (Cousens et al., 1997)...
To date the OIE/WAHO assumes that the human and animal health standards set
out in the BSE chapter for classical BSE (C-Type) applies to all forms of BSE
which include the H-type and L-type atypical forms. This assumption is
scientifically not completely justified and accumulating evidence suggests that
this may in fact not be the case. Molecular characterization and the spatial
distribution pattern of histopathologic lesions and immunohistochemistry (IHC)
signals are used to identify and characterize atypical BSE. Both the L-type and
H-type atypical cases display significant differences in the conformation and
spatial accumulation of the disease associated prion protein (PrPSc) in brains
of afflicted cattle. Transmission studies in bovine transgenic and wild type
mouse models support that the atypical BSE types might be unique strains because
they have different incubation times and lesion profiles when compared to C-type
BSE. When L-type BSE was inoculated into ovine transgenic mice and Syrian
hamster the resulting molecular fingerprint had changed, either in the first or
a subsequent passage, from L-type into C-type BSE.
***In addition, non-human primates are specifically susceptible for
atypical BSE as demonstrated by an approximately 50% shortened incubation time
for L-type BSE as compared to C-type. Considering the current scientific
information available, it cannot be assumed that these different BSE types pose
the same human health risks as C-type BSE or that these risks are mitigated by
the same protective measures.
-------- Original Message --------
Subject: re-BSE prions propagate as either variant CJD-like or sporadic CJD
Date: Thu, 28 Nov 2002 10:23:43 -0000
From: "Asante, Emmanuel A" e.asante@ic.ac.uk
To: "'flounder@wt.net'" flounder@wt.net
Dear Terry,
I have been asked by Professor Collinge to respond to your request. I am a
Senior Scientist in the MRC Prion Unit and the lead author on the paper. I have
attached a pdf copy of the paper for your attention.
Thank you for your interest in the paper.
In respect of your first question, the simple answer is, ***yes. As you
will find in the paper, we have managed to associate the alternate phenotype to
type 2 PrPSc, the commonest sporadic CJD. It is too early to be able to claim
any further sub-classification in respect of Heidenhain variant CJD or Vicky
Rimmer's version. It will take further studies, which are on-going, to establish
if there are sub-types to our initial finding which we are now reporting. The
main point of the paper is that, as well as leading to the expected new variant
CJD phenotype, BSE transmission to the 129-methionine genotype can lead to an
alternate phenotype which is indistinguishable from type 2 PrPSc.
I hope reading the paper will enlighten you more on the subject. If I can
be of any further assistance please to not hesitate to ask. Best wishes.
Emmanuel Asante
<>
____________________________________
Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial
College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG Tel: +44
(0)20 7594 3794 Fax: +44 (0)20 7706 3272 email: e.asante@ic.ac.uk (until
9/12/02) New e-mail: e.asante@prion.ucl.ac.uk (active from now)
____________________________________
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection
against prion diseases is based on a certain numbers of hypotheses some of which
may turn out to be erroneous. In particular, a form of BSE (called atypical
Bovine Spongiform Encephalopathy), recently identified by systematic testing in
aged cattle without clinical signs, may be the origin of classical BSE and thus
potentially constitute a reservoir, which may be impossible to eradicate if a
sporadic origin is confirmed.
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC)
recently delivered a scientific opinion on any possible epidemiological or
molecular association between TSEs in animals and humans (EFSA Panel on
Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical
BSE prions as the only TSE agents demonstrated to be zoonotic so far
*** but the possibility that a small proportion of human cases so far
classified as "sporadic" CJD are of zoonotic origin could not be excluded.
Moreover, transmission experiments to non-human primates suggest that some TSE
agents in addition to Classical BSE prions in cattle (namely L-type Atypical
BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic
wasting disease (CWD) agents) might have zoonotic potential.
snip...
Tuesday, November 04, 2014
The pathological and molecular but not clinical phenotypes are maintained
after second passage of experimental atypical bovine spongiform encephalopathy
in cattle
*** HUMAN MAD COW DISEASE nvCJD TEXAS CASE NOT LINKED TO EUROPEAN TRAVEL
CDC ***
Sunday, November 23, 2014
*** Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas
in June 2014 confirmed as USA case NOT European
the patient had resided in Kuwait, Russia and Lebanon. The completed
investigation did not support the patient's having had extended travel to
European countries, including the United Kingdom, or travel to Saudi Arabia. The
specific overseas country where this patient’s infection occurred is less clear
largely because the investigation did not definitely link him to a country where
other known vCJD cases likely had been infected.
Sunday, December 14, 2014
ALERT new variant Creutzfeldt Jakob Disease nvCJD or vCJD, sporadic CJD
strains, TSE prion aka Mad Cow Disease United States of America Update December
14, 2014 Report
TSS
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